Objective 11

 

Functionalization of chaperonins

 

Chaperonins are a group of chaperones with a structure formed by two back-to-back rings. The cavity between the rings can be closed through ATP, which induces a conformational change that controls the lock of the ring. In principle, chaperonins can be considered as biological containers (with an internal volume of 100-130 kÅ3), and several approaches, in which the cavity can be closed and opened at will, has been developed in the past. Therefore, nanocontainers with the ability of encapsulate a large amount of molecules can be prepared.