Objective 10

 

 Development and optimization of degradosomes

 

One of the essential routes within the protein degradation, whose proper operation may lead to different types of neurodegenerative diseases, is the liposomal one. This process is controlled by certain proteins, mainly chaperonins, which are placed at the external membrane and at the inner of lysosomes. The objective is the development of controlled artificial structures (degradosomes) that reproduce the function of lysosomes.